Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis.

ABSTRACT: During interphase, recycling endosomes mediate the transport of internalized cargo back to the plasma membrane. However, in mitotic cells, recycling endosomes are essential for the completion of cytokinesis, the last phase of mitosis that promotes the physical separation the two daughter cells. Despite recent advances, our understanding of the molecular determinants that regulate recycling endosome dynamics during cytokinesis remains incomplete. We have previously demonstrated that Molecule Interacting with CasL Like-1 (MICAL-L1) and C-terminal Eps15 Homology Domain protein 1 (EHD1) coordinately regulate receptor transport from tubular recycling endosomes during interphase. However, their potential roles in controlling cytokinesis had not been addressed. In this study, we show that MICAL-L

SUBMITTER: Reinecke JB 

PROVIDER: S-EPMC4275409 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature