Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk.

ABSTRACT:

Background

The recently described interaction between smoking, human leukocyte antigen (HLA) DRB1*15 and absence of HLA-A*02 with regard to multiple sclerosis (MS) risk shows that the risk conveyed by smoking differs depending on genetic background. We aimed to investigate whether a similar interaction exists between passive smoking and HLA genotype.

Methods

We used one case-control study with incident cases of MS (736 cases, 1195 controls) and one with prevalent cases (575 cases, 373 controls). Never-smokers with different genotypes and passive smoking status were compared with regard to occurrence of MS, by calculating odds ratios (ORs) with 95% confidence intervals (CIs). The potential interaction between different genotypes and passive smoking was evaluated by calculatin

SUBMITTER: Hedstrom AK 

PROVIDER: S-EPMC4276064 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature