Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.

ABSTRACT: Previous studies have shown that the single nucleotide polymorphisms (SNPs) in Methylenetetrahydrofolate reductase (MTHFR) and Glutathione S-transferases (GSTs, including GSTM1, GSTT1) genes play an important role in determining the response of an individual to environmental pathogenesis and significantly relate to incidences of various human tumors, including brain tumors. However, these genes' polymorphisms on meningioma risk remains poorly understood. The relevant inferences from previous studies are hindered by their limited statistical power and conflicting results. The aim of this meta-analysis is to provide a relatively comprehensive account of the association between these polymorphisms and human meningioma risk. A literature search for eligible studies published before January 1,

SUBMITTER: Ding H 

PROVIDER: S-EPMC4276156 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature