Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth.

ABSTRACT:

Objective

To determine the impact of pediatric-onset multiple sclerosis (MS) on age-expected brain growth.

Methods

Whole brain and regional volumes of 36 patients with relapsing-remitting MS onset prior to 18 years of age were segmented in 185 longitudinal MRI scans (2-11 scans per participant, 3-month to 2-year scan intervals). MRI scans of 25 age- and sex-matched healthy normal controls (NC) were also acquired at baseline and 2 years later on the same scanner as the MS group. A total of 874 scans from 339 participants from the NIH-funded MRI study of normal brain development acquired at 2-year intervals were used as an age-expected healthy growth reference. All data were analyzed with an automatic image processing pipeline to estimate the volume of brain and brain substruc

SUBMITTER: Aubert-Broche B 

PROVIDER: S-EPMC4276405 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature