Identification of a novel intertypic recombinant species D human adenovirus in a pediatric stem cell transplant recipient.

ABSTRACT:

Background

Human adenoviruses (HAdV) are known opportunistic pathogens in hematopoietic stem cell transplant (SCT) recipients. The detection of HAdV infection in children after SCT has been implicated as a determinant of poor outcome but specific associations between HAdV species or individual HAdV types and disease are poorly understood.

Objectives

Characterization of a HAdV-D strain isolated from multiple clinical specimens of an 11-year-old female recipient of a matched unrelated donor peripheral SCT for T-cell lymphoma and case report.

Study design

Archived HAdV PCR-positive plasma, urine, and stool specimens were processed for virus isolation and detailed molecular typing. Complete genomic sequencing was carried out on 2 isolates.

Results

The patient teste

SUBMITTER: Kajon AE 

PROVIDER: S-EPMC4276453 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature