Local control and toxicity in a large cohort of central lung tumors treated with stereotactic body radiation therapy.

ABSTRACT:

Purpose

Stereotactic body radiation therapy (SBRT) in central lung tumors has been associated with higher rates of severe toxicity. We sought to evaluate toxicity and local control in a large cohort and to identify predictive dosimetric parameters.

Methods and materials

We identified patients who received SBRT for central tumors according to either of 2 definitions. Local failure (LF) was estimated using a competing risks model, and multivariate analysis (MVA) was used to assess factors associated with LF. We reviewed patient toxicity and applied Cox proportional hazard analysis and log-rank tests to assess whether dose-volume metrics of normal structures correlated with pulmonary toxicity.

Results

One hundred twenty-five patients received SBRT for non-small cell lung

SUBMITTER: Modh A 

PROVIDER: S-EPMC4276458 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature