Novel risk factors for recurrent Clostridium difficile infection in children.

ABSTRACT:

Objectives

Clostridium difficile, a common cause of antibiotic-associated diarrhea, has been reported to recur in high rates in adults. The rates and risk factors for recurrent C difficile infection (rCDI) in children have not been well established.

Methods

We conducted a retrospective cohort study of 186 pediatric patients seen at a tertiary care referral center for a 5-year period diagnosed as having a primary C difficile infection. Children with recurrent disease, defined as return of symptoms of C difficile infection and positive testing ≤60 days after the completion of therapy, were compared with children who did not experience an episode of recurrence.

Results

Of the 186 pediatric patients included in this study, 41 (22%) experienced rCDI. On univariable analysi

SUBMITTER: Nicholson MR 

PROVIDER: S-EPMC4276518 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature