Fetal assessment before and after dosing with buprenorphine or methadone.

ABSTRACT:

Aim

To determine pre- and post-dosing effects of prenatal methadone compared to buprenorphine on fetal wellbeing.

Design

A secondary analysis of data derived from the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a double-blind, double-dummy, randomized clinical trial.

Setting

Six United States sites and one European site that provided comprehensive opioid-dependence treatment to pregnant women.

Participants

Eighty-one of the 131 opioid-dependent pregnant women completing the MOTHER clinical trial, assessed between 31 and 33 weeks of gestation.

Measurements

Two fetal assessments were conducted, once before and once after study medication dosing. Measures included mean fetal heart rate (FHR), number of FHR accelerations, FHR react

SUBMITTER: Salisbury AL 

PROVIDER: S-EPMC4277183 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature