Ontology highlight
ABSTRACT:
SUBMITTER: Pan H
PROVIDER: S-EPMC4277258 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cell reports 20140320 1
Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remains unclear. Here, we show that whole-body conditional deletion of the B subunit of NELF (NELF-B) in adult mice results in cardiomyopathy and impaired response to cardiac stress. Tissue-specific knockout of NELF-B confirms its cell-autonomous function in card ...[more]