Effector memory CD4(+) T cells are associated with cognitive performance in a senior population.

ABSTRACT:

Objective

Immunosenescence and cognitive decline are common markers of the aging process. Taking into consideration the heterogeneity observed in aging processes and the recently described link between lymphocytes and cognition, we herein explored the possibility of an association between alterations in lymphocytic populations and cognitive performance.

Methods

In a cohort of cognitively healthy adults (n = 114), previously characterized by diverse neurocognitive/psychological performance patterns, detailed peripheral blood immunophenotyping of both the innate and adaptive immune systems was performed by flow cytometry.

Results

Better cognitive performance was associated with lower numbers of effector memory CD4(+) T cells and higher numbers of naive CD8(+) T cells an

SUBMITTER: Serre-Miranda C 

PROVIDER: S-EPMC4277304 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature