Allele Workbench: transcriptome pipeline and interactive graphics for allele-specific expression.

ABSTRACT: Sequencing the transcriptome can answer various questions such as determining the transcripts expressed in a given species for a specific tissue or condition, evaluating differential expression, discovering variants, and evaluating allele-specific expression. Differential expression evaluates the expression differences between different strains, tissues, and conditions. Allele-specific expression evaluates expression differences between parental alleles. Both differential expression and allele-specific expression have been studied for heterosis (hybrid vigor), where the hybrid has improved performance over the parents for one or more traits. The Allele Workbench software was developed for a heterosis study that evaluated allele-specific expression for a mouse F1 hybrid using libraries from

SUBMITTER: Soderlund CA 

PROVIDER: S-EPMC4277417 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature