Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.

ABSTRACT: Ser/Thr- and Tyr-Protein kinases constitute a key switch underlying the dynamic nature and graded regulation of signal transduction and pathway activities in cellular organization. Here we describe the identification and characterization of Dusty, a single-copy gene that arose in metazoan evolution and encodes a putative dual Ser/Thr and Tyr protein kinase with unique structural features. Dusty is widely expressed in vertebrates, broadly distributed in the central nervous system, and deregulated in certain human cancers. Confocal imaging of transiently expressed human Dusty-GFP fusion proteins showed a cytoplasmic distribution. Dusty proteins from lower to higher species display an increasing degree of sequence conservation from the N-terminal non-catalytic domain to C-terminal catalytic d

SUBMITTER: Peng J 

PROVIDER: S-EPMC4277547 | biostudies-literature | 2006 Nov-Dec

REPOSITORIES: biostudies-literature