CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle.

ABSTRACT:

Background

The multi-meric calcium/calmodulin-dependent protein kinase II (CaMKII) is the main CaMK in skeletal muscle and its expression increases with endurance training. CaMK family members are implicated in contraction-induced regulation of calcium handling, fast myosin type IIA expression and mitochondrial biogenesis. The objective of this study was to investigate the role of an increased CaMKII content for the expression of the contractile and mitochondrial phenotype in vivo. Towards this end we attempted to co-express alpha- and beta-CaMKII isoforms in skeletal muscle and characterised the effect on the contractile and mitochondrial phenotype.

Results

Fast-twitch muscle m. gastrocnemius (GM) and slow-twitch muscle m. soleus (SOL) of the right leg of 3-month old rats w

SUBMITTER: Eilers W 

PROVIDER: S-EPMC4277655 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature