LRRK2 exonic variants and risk of multiple system atrophy.

ABSTRACT:

Objective

The aim of this study was to evaluate the association between common exonic variants in the leucine-rich repeat kinase 2 (LRRK2) gene and risk of multiple system atrophy (MSA).

Methods

One series from the United States (92 patients with pathologically confirmed MSA, 416 controls) and a second series from the United Kingdom (85 patients with pathologically confirmed MSA, 352 controls) were included in this case-control study. We supplemented these data with those of 53 patients from the United States with clinically probable or possible MSA. Seventeen common LRRK2 exonic variants were genotyped and assessed for association with MSA.

Results

In the combined series of 177 patients with pathologically confirmed MSA and 768 controls, there was a significant assoc

SUBMITTER: Heckman MG 

PROVIDER: S-EPMC4277668 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature