Epitope spreading as an early pathogenic event in pediatric multiple sclerosis.

ABSTRACT:

Objectives

For most adults with initial clinical presentation of multiple sclerosis (MS), biological disease was likely initiated many years prior. Pediatric-onset MS provides an opportunity to study early disease processes.

Methods

Using antigen microarrays, including CNS-related proteins, lipids, and other autoantigens, we studied early immunologic events involved in clinical onset of pediatric MS. Serum samples were collected at the time of incident acquired CNS demyelinating syndromes (ADS) in children who, in subsequent prospective follow-up, were ascertained to have either pediatric MS (ADS-MS) or a monophasic illness (ADS-mono). Samples were obtained both at the time of ADS presentation and 3 months into follow-up. We used an initial training set of samples to implica

SUBMITTER: Quintana FJ 

PROVIDER: S-EPMC4277672 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature