Risk factors for montelukast treatment failure in step-down therapy for controlled asthma.

ABSTRACT:

Background

Leukotriene receptor antagonists including montelukast are an option for step-down therapy for mild asthmatics controlled on low-dose inhaled corticosteroids (ICS). Because some patients fail montelukast step-down therapy, it would be helpful for clinicians to be able to predict the risk of treatment failure.

Objectives

To determine patient characteristics associated with montelukast treatment failure and develop a clinical index to predict the risk of montelukast treatment failure.

Methods

Using the 165 participants in the Leukotriene or Corticosteroid or Corticosteroid-Salmeterol Study (LOCCS) trial who were stepped down from low-dose ICS to montelukast, we determined associations between enrollment variables and treatment failure. We constructed a montel

SUBMITTER: Drummond MB 

PROVIDER: S-EPMC4277696 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature