Measurement of evoked potentials during thalamic deep brain stimulation.

ABSTRACT:

Background

Deep brain stimulation (DBS) treats the symptoms of several movement disorders, but optimal selection of stimulation parameters remains a challenge. The evoked compound action potential (ECAP) reflects synchronized neural activation near the DBS lead, and may be useful for feedback control and automatic adjustment of stimulation parameters in closed-loop DBS systems.

Objectives

Determine the feasibility of recording ECAPs in the clinical setting, understand the neural origin of the ECAP and sources of any stimulus artifact, and correlate ECAP characteristics with motor symptoms.

Methods

The ECAP and tremor response were measured simultaneously during intraoperative studies of thalamic DBS, conducted in patients who were either undergoing surgery for initial

SUBMITTER: Kent AR 

PROVIDER: S-EPMC4277712 | biostudies-literature | 2015 Jan-Feb

REPOSITORIES: biostudies-literature