Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation.

ABSTRACT:

Background

Atherosclerotic animal models show increased recruitment of inflammatory cells to the heart after myocardial infarction (MI), which impacts ventricular function and remodeling.

Objective

The purpose of this study was to determine whether increased myocardial inflammation after MI also contributes to arrhythmias.

Methods

MI was created in 3 mouse models: (1) atherosclerotic (apolipoprotein E deficient [ApoE(-/-)] on atherogenic diet, n = 12); (2) acute inflammation (wild-type [WT] given daily lipopolysaccharide [LPS] 10 μg/day, n = 7); and (3) WT (n = 14). Sham-operated (n = 4) mice also were studied. Four days post-MI, an inflammatory protease-activatable fluorescent probe (Prosense680) was injected intravenously to quantify myocardial inflammation on day 5

SUBMITTER: De Jesus NM 

PROVIDER: S-EPMC4277908 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature