DNA modification study of major depressive disorder: beyond locus-by-locus comparisons.

ABSTRACT:

Background

Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined.

Methods

We performed DNA modification analysis in white blood cells from monozygotic twins discordant for MDD, in brain prefrontal cortex, and germline (sperm) samples from affected individuals and control subjects (total N = 304) using 8.1K CpG island microarrays and fine mapping. In addition to the traditional locus-by-locus comparisons, we explored the potential of new analytical approaches in epigenomic studies.

Results

In the microarray experiment, we detected a number of nomi

SUBMITTER: Oh G 

PROVIDER: S-EPMC4277915 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature