Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).

ABSTRACT:

Background

MicroRNAs (miRNAs) are associated with cardiovascular disease and control gene expression and are detectable in the circulation.

Objective

The purpose of this study was to test the hypothesis that circulating miRNAs may be associated with atrial fibrillation (AF).

Methods

Using a prospective study design powered to detect subtle differences in miRNAs, we quantified plasma expression of 86 miRNAs by high-throughput quantitative reverse transcriptase-polymerase chain reaction in 112 participants with AF and 99 without AF. To examine parallels between cardiac and plasma miRNA profiles, we quantified atrial tissue and plasma miRNA expression using quantitative reverse transcriptase-polymerase chain reaction in 31 participants undergoing surgery. We also explore

SUBMITTER: McManus DD 

PROVIDER: S-EPMC4277933 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature