Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1.

ABSTRACT:

Background

Long QT syndrome type 1 (LQT1) is a congenital disease arising from a loss of function in the slowly activating delayed potassium current IKs, which causes early afterdepolarizations (EADs) and polymorphic ventricular tachycardia (pVT).

Objective

The purpose of this study was to investigate the mechanisms underlying pVT using a transgenic rabbit model of LQT1.

Methods

Hearts were perfused retrogradely, and action potentials were recorded using a voltage-sensitive dye and CMOS cameras.

Results

Bolus injection of isoproterenol (140 nM) induced pVT initiated by focal excitations from the right ventricle (RV; n = 16 of 18 pVTs). After the pVT was initiated, complex focal excitations occurred in both the RV and the left ventricle, which caused oscillation

SUBMITTER: Kim TY 

PROVIDER: S-EPMC4277941 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature