Association of genetic polymorphisms of EGFR with glioma in a Chinese population.

ABSTRACT:

Objective

Several studies indicated that genetic polymorphisms in the epidermal growth factor receptor (EGFR) gene were associated with glioma risk. However, the relationship between EGFR genetic polymorphisms and glioma remains unclear in the Chinese population.

Methods

We designed a case-control study by selecting 300 histologically confirmed adult glioma patients and 300 cancer-free controls to analyze the distribution of EGFR genotype. Two single-nucleotide polymorphisms, rs730437 and rs1468727, were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism method.

Results

We found that the CC genotype of rs1468727 was more common in the glioma group than in the control group (p=0.021). We also found that the C allele frequency was

SUBMITTER: Wang X 

PROVIDER: S-EPMC4278171 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature