Secocrassumol, a seco-cembranoid from the Dongsha Atoll soft coral Lobophytum crassum.

ABSTRACT: Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher's acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 μg/mL.

SUBMITTER: Cheng SY 

PROVIDER: S-EPMC4278217 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature