HIV drug resistance detected during low-level viraemia is associated with subsequent virologic failure.

ABSTRACT:

Background

The clinical implications of emergent HIV drug resistance on samples with low-level viraemia (LLV <1000 copies/ml) remain unclear. We undertook the present analysis to evaluate the impact of emergent HIV drug resistance at LLV on the risk of subsequent virologic failure.

Methods

One thousand, nine hundred and sixty-five patients had genotype results at LLV. Risk of virologic failure (≥1000 copies/ml) after LLV was evaluated by Kaplan-Meier analysis and Cox proportional hazards regression. Resistance was assessed using the Stanford algorithm or virtual phenotypes. Patients were grouped into four susceptibility categories ('GSS' or 'vPSS') during LLV, corresponding to the number of 'active' drugs prescribed: <1; 1-1.5; 2-2.5; and ≥3.

Results

A total of 1702 p

SUBMITTER: Swenson LC 

PROVIDER: S-EPMC4278403 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature