Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected individuals.

ABSTRACT:

Aim

To examine the relationship between inflammatory and coagulation biomarkers and cardiac autonomic function (CAF) as measured by heart rate variability in persons with HIV.

Materials & methods

This analysis included 4073 HIV-infected persons from the Strategies for Management of Antiretroviral Therapy study. We examined the association between IL-6, high-sensitivity C-reactive protein (hsCRP) and D-dimer with heart rate variability measures (SDNN and rMSSD), both cross-sectionally and longitudinally.

Results

Cross-sectional analysis revealed significant inverse associations between IL-6, hsCRP and d-dimer with SDNN and rMSSD (p < 0.01 for all comparisons). However, longitudinal analysis failed to show a significant association between baseline IL-6, hsCRP and d-dim

SUBMITTER: Young LC 

PROVIDER: S-EPMC4278423 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature