A ranking of diffusion MRI compartment models with in vivo human brain data.

ABSTRACT:

Purpose

Diffusion magnetic resonance imaging (MRI) microstructure imaging provides a unique noninvasive probe into tissue microstructure. The technique relies on biophysically motivated mathematical models, relating microscopic tissue features to the magnetic resonance (MR) signal. This work aims to determine which compartment models of diffusion MRI are best at describing measurements from in vivo human brain white matter.

Methods

Recent work shows that three compartment models, designed to capture intra-axonal, extracellular, and isotropically restricted diffusion, best explain multi-b-value data sets from fixed rat corpus callosum. We extend this investigation to in vivo by using a live human subject on a clinical scanner. The analysis compares models of one, two, and thr

SUBMITTER: Ferizi U 

PROVIDER: S-EPMC4278549 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature