Low-dose intramuscular dexmedetomidine as premedication: a randomized controlled trial.

ABSTRACT:

Background

Dexmedetomidine-induced bradycardia or hypotension has recently attracted considerable attention because of potentially grave consequences, including sinus arrest and refractory cardiogenic shock. A route other than intravenous injection or a low dose may help minimize cardiovascular risks associated with dexmedetomidine. However, few studies have addressed the clinical effects of low-dose intramuscular dexmedetomidine as premedication.

Material and methods

Forty American Society of Anesthesiologists physical status I adult patients undergoing suspension laryngoscopic surgery were randomized to receive intramuscular dexmedetomidine (1 µg·kg-1) or midazolam (0.02 mg·kg-1) 30 minutes prior to anaesthesia induction. The sedative, hemodynamic, and adjuvant anaesthetic

SUBMITTER: Sun Y 

PROVIDER: S-EPMC4278696 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature