Systems immunology reveals markers of susceptibility to West Nile virus infection.

ABSTRACT: West Nile virus (WNV) infection is usually asymptomatic but can cause severe neurological disease and death, particularly in older patients, and how individual variations in immunity contribute to disease severity is not yet defined. Animal studies identified a role for several immunity-related genes that determine the severity of infection. We have integrated systems-level transcriptional and functional data sets from stratified cohorts of subjects with a history of WNV infection to define whether these markers can distinguish susceptibility in a human population. Transcriptional profiles combined with immunophenotyping of primary cells identified a predictive signature of susceptibility that was detectable years after acute infection (67% accuracy), with the most prominent alteration bei

SUBMITTER: Qian F 

PROVIDER: S-EPMC4278927 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature