A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers.

ABSTRACT:

Rationale

There is presently no approved single treatment for dual alcohol and nicotine dependencies.

Objective

This pilot study investigated baclofen effects in alcoholic smokers.

Methods

This was a preliminary double-blind placebo-controlled randomized clinical study with 30 alcoholic smokers randomized to baclofen at 80 mg/day or placebo. A subgroup (n=18) participated in an alcohol cue-reactivity experiment.

Results

Baclofen, compared with placebo, significantly decreased the percent days of abstinence from alcohol-tobacco co-use (p=0.004). Alcohol dependence severity moderated baclofen effects, with the higher severity group having the greater baclofen response (p<0.001). Although the percent days of alcohol-tobacco co-use declined in both groups, this dec

SUBMITTER: Leggio L 

PROVIDER: S-EPMC4278944 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature