Anaerobic antimicrobial therapy after necrotizing enterocolitis in VLBW infants.

ABSTRACT:

Objective

To evaluate the effect of anaerobic antimicrobial therapy for necrotizing enterocolitis (NEC) on clinical outcomes in very low birth weight (≤1500 g) infants.

Methods

We identified very low birth weight infants with NEC from 348 US NICUs from 1997 to 2012. Anaerobic antimicrobial therapy was defined by antibiotic exposure on the first day of NEC. We matched (1:1) infants exposed to anaerobic antimicrobial therapy with infants who were not exposed by using a propensity score stratified by NEC severity (medical and surgical). The primary composite outcome was in-hospital death or intestinal stricture. We assessed the relationship between anaerobic antimicrobial therapy and outcome by using a conditional logistic regression on the matched cohort.

Results

A tota

SUBMITTER: Autmizguine J 

PROVIDER: S-EPMC4279070 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature