Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder.

ABSTRACT: Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use disorder with significant morbidity. Major advances have been made in delineating neurobiological mechanisms of cocaine abuse; however, effective medications to treat cocaine use disorder remain to be discovered. The present review will focus on the role of serotonin (5-HT; 5-hydroxytryptamine) neurotransmission in the neuropharmacology of cocaine and related abused stimulants. Extensive research suggests that the primary contribution of 5-HT to cocaine addiction is a consequence of interactions with dopamine (DA) neurotransmission. The literature on the neurobiological and behavioral effects of cocaine is well developed, so the focus of the review will be on cocaine with inferences made about other mon

SUBMITTER: Howell LL 

PROVIDER: S-EPMC4279075 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature