Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.

ABSTRACT:

Background

The pathogenesis of inflammatory bowel disease (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosal immune responses through the pattern recognition receptor. Polymorphisms in toll-like receptor 4 (TLR4) induce an aberrant immune response to indigenous intestinal flora, which might favor IBD development. In this study, we aimed to determine whether TLR4 gene was associated with Crohn's disease (CD) and ulcerative colitis (UC) among Moroccan patients, and evaluated its correlation with clinical manifestation of the disease.

Methods

The study population comprised 117 patients with IBD and 112 healthy unrelated blood donors. TLR4 polymorphisms: Asp299Gly and Thr399Ile were genotyped by polymerase chain reaction-restri

SUBMITTER: Senhaji N 

PROVIDER: S-EPMC4279599 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature