Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Hainan population: a case-control study.

ABSTRACT:

Purpose

Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and the fifth most common cause of disability in the world by 2020. Recently, variants in the hypoxia-inducible factor 1α (HIF1A), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, and iron-responsive element-binding protein 2 gene (IREB2) genes were found to be associated with COPD. This study aims to identify whether the variations in these genes are related to COPD in the Hainan population of the People's Republic of China.

Patients and methods

We genotyped 12 single nucleotide polymorphisms in a case-control study with 200 COPD cases and 401 controls from Hainan, People's Republic of China. Odds ratios and 95% confidence intervals were estimated u

SUBMITTER: Ding Y 

PROVIDER: S-EPMC4279605 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature