TE-Tracker: systematic identification of transposition events through whole-genome resequencing.

ABSTRACT:

Background

Transposable elements (TEs) are DNA sequences that are able to move from their location in the genome by cutting or copying themselves to another locus. As such, they are increasingly recognized as impacting all aspects of genome function. With the dramatic reduction in cost of DNA sequencing, it is now possible to resequence whole genomes in order to systematically characterize novel TE mobilization in a particular individual. However, this task is made difficult by the inherently repetitive nature of TE sequences, which in some eukaryotes compose over half of the genome sequence. Currently, only a few software tools dedicated to the detection of TE mobilization using next-generation-sequencing are described in the literature. They often target specific TEs for which an

SUBMITTER: Gilly A 

PROVIDER: S-EPMC4279814 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature