Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study.

ABSTRACT:

Background

Propensity for alcohol misuse may be linked to an individuals' response to alcohol. This study examined the role of alcohol response phenotypes to future drinking problems.

Methods

One hundred four young heavy social drinkers participated in a within-subject, double-blind, placebo-controlled laboratory alcohol challenge study with 6-year follow-up. Participants were examined for subjective responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beverage, given in random order. Follow-up was conducted in 5 waves over 6 years after the sessions to assess drinking behaviors and alcohol use disorder (AUD) symptoms. Retention was high with 98% (509 of 520) of possible follow-ups completed.

Results

Greater sensitivity to alcoho

SUBMITTER: King AC 

PROVIDER: S-EPMC4280017 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature