Liposomal spherical nucleic acids.
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ABSTRACT:
SUBMITTER: Banga RJ
PROVIDER: S-EPMC4280063 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Liposomal spherical nucleic acids.
Banga Resham J RJ Chernyak Natalia N Narayan Suguna P SP Nguyen SonBinh T ST Mirkin Chad A CA
Journal of the American Chemical Society 20140701 28
A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architectur ...[more]
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