The influence of promoter architectures and regulatory motifs on gene expression in Escherichia coli.

ABSTRACT: The ability to regulate gene expression is of central importance for the adaptability of living organisms to changes in their external and internal environment. At the transcriptional level, binding of transcription factors (TFs) in the promoter region can modulate the transcription rate, hence making TFs central players in gene regulation. For some model organisms, information about the locations and identities of discovered TF binding sites have been collected in continually updated databases, such as RegulonDB for the well-studied case of E. coli. In order to reveal the general principles behind the binding-site arrangement and function of these regulatory architectures we propose a random promoter architecture model that preserves the overall abundance of binding sites to identify over

SUBMITTER: Rydenfelt M 

PROVIDER: S-EPMC4280137 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature