Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

ABSTRACT:

Background

To date, no genome-wide association study (GWAS) has considered the combined phenotype of asthma with hay fever. Previous analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma without hay fever.

Objective

We sought to perform a GWAS of asthma with hay fever to identify variants associated with having both diseases.

Methods

We performed a meta-analysis of GWASs comparing persons with both physician-diagnosed asthma and hay fever (n = 6,685) with persons with neither disease (n = 14,091).

Results

At genome-wide significance, we identified 11 independent variants associated with the risk of having asthma with hay fever, including 2 associations reaching this lev

SUBMITTER: Ferreira MA 

PROVIDER: S-EPMC4280183 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature