Structure based annotation of Helicobacter pylori strain 26695 proteome.

ABSTRACT: The availability of complete genome sequences of H. pylori 26695 has provided a wealth of information enabling us to carry out in silico studies to identify new molecular targets for pharmaceutical treatment. In order to construe the structural and functional information of complete proteome, use of computational methods are more relevant since these methods are reliable and provide a solution to the time consuming and expensive experimental methods. Out of 1590 predicted protein coding genes in H. pylori, experimentally determined structures are available for only 145 proteins in the PDB. In the absence of experimental structures, computational studies on the three dimensional (3D) structural organization would help in deciphering the protein fold, structure and active site. Functional an

SUBMITTER: Singh S 

PROVIDER: S-EPMC4280198 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature