Kinomic profiling of electromagnetic navigational bronchoscopy specimens: a new approach for personalized medicine.

ABSTRACT:

Purpose

Researchers are currently seeking relevant lung cancer biomarkers in order to make informed decisions regarding therapeutic selection for patients in so-called "precision medicine." However, there are challenges to obtaining adequate lung cancer tissue for molecular analyses. Furthermore, current molecular testing of tumors at the genomic or transcriptomic level are very indirect measures of biological response to a drug, particularly for small molecule inhibitors that target kinases. Kinase activity profiling is therefore theorized to be more reflective of in vivo biology than many current molecular analysis techniques. As a result, this study seeks to prove the feasibility of combining a novel minimally invasive biopsy technique that expands the number of lesions amenable

SUBMITTER: Anderson JC 

PROVIDER: S-EPMC4280210 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature