Oxytocin administration enhances controlled social cognition in patients with schizophrenia.

ABSTRACT:

Background

Individuals with schizophrenia have functionally significant deficits in automatic and controlled social cognition, but no currently available pharmacologic treatments reduce these deficits. The neuropeptide oxytocin has multiple prosocial effects when administered intranasally in humans and there is growing interest in its therapeutic potential in schizophrenia.

Methods

We administered 40 IU of oxytocin and saline placebo intranasally to 29 male subjects with schizophrenia and 31 age-matched, healthy controls in a randomized, double-blind, placebo-controlled, cross-over study. Social cognition was assessed with The Awareness of Social Inference Test (TASIT) and the Reading the Mind in the Eyes Test (RMET). We examined the effects of oxytocin administration on aut

SUBMITTER: Woolley JD 

PROVIDER: S-EPMC4280262 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature