Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration.

ABSTRACT:

Unlabelled

Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known. The aims of this work were to generate an animal model that fails to stop liver regeneration after surgical resections and elucidate mechanisms that are involved in termination of liver regeneration. Because epigenetic control of liver function has been previously implicated in the regulation of liver proliferation, we generated C/EBPα-S193A knockin mice, which have alterations in formation of complexes of C/EBP family proteins with chromatin remodeling proteins. The C/EBPα-S193A mice have altered liver morphology and alte

SUBMITTER: Jin J 

PROVIDER: S-EPMC4280321 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature