Five-year nationwide follow-up study of active surveillance for prostate cancer.

ABSTRACT:

Background

Active surveillance (AS) is an important yet underutilized strategy to reduce prostate cancer (PCa) overtreatment.

Objective

To examine the 5-yr outcomes of AS in a population-based setting.

Design, setting, and participants

From the National Prostate Cancer Register of Sweden, we identified 11 726 men ≤70 yr diagnosed with very low-risk to intermediate-risk PCa from 2003 to 2007 who completed 5 yr of follow-up. Of these men, 1729 (15%) chose AS for the primary management strategy.

Outcome measurements and statistical analysis

We calculated the probability of discontinuation of AS over time, and Cox proportional hazards models were used to determine factors associated with discontinuation. Reasons for discontinuation were assessed by data extraction

SUBMITTER: Loeb S 

PROVIDER: S-EPMC4280355 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature