Context-dependent incremental timing cells in the primate hippocampus.

ABSTRACT: We examined timing-related signals in primate hippocampal cells as animals performed an object-place (OP) associative learning task. We found hippocampal cells with firing rates that incrementally increased or decreased across the memory delay interval of the task, which we refer to as incremental timing cells (ITCs). Three distinct categories of ITCs were identified. Agnostic ITCs did not distinguish between different trial types. The remaining two categories of cells signaled time and trial context together: One category of cells tracked time depending on the behavioral action required for a correct response (i.e., early vs. late release), whereas the other category of cells tracked time only for those trials cued with a specific OP combination. The context-sensitive ITCs were observed m

SUBMITTER: Sakon JJ 

PROVIDER: S-EPMC4280595 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature