αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

ABSTRACT: Proalgesic sensitization of peripheral nociceptors in painful syndromes is a complex molecular process poorly understood that involves mobilization of thermosensory receptors to the neuronal surface. However, whether recruitment of vesicular thermoTRP channels is a general mechanism underlying sensitization of all nociceptor types or is subtype-specific remains controversial. We report that sensitization-induced Ca(2+)-dependent exocytotic insertion of transient receptor potential vanilloid 1 (TRPV1) receptors to the neuronal plasma membrane is a mechanism specifically used by peptidergic nociceptors to potentiate their excitability. Notably, we found that TRPV1 is present in large dense-core vesicles (LDCVs) that were mobilized to the neuronal surface in response to a sensitizing insult.

SUBMITTER: Devesa I 

PROVIDER: S-EPMC4280602 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature