HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.

ABSTRACT: The efficacy of hormonal therapies for advanced estrogen receptor-positive breast cancers is limited by the nearly inevitable development of acquired resistance. Efforts to block the emergence of resistance have met with limited success, largely because the mechanisms underlying it are so varied and complex. Here, we investigate a new strategy aimed at the very processes by which cancers evolve resistance. From yeast to vertebrates, heat shock protein 90 (HSP90) plays a unique role among molecular chaperones by promoting the evolution of heritable new traits. It does so by regulating the folding of a diverse portfolio of metastable client proteins, many of which mediate adaptive responses that allow organisms to adapt and thrive in the face of diverse challenges, including those posed by d

SUBMITTER: Whitesell L 

PROVIDER: S-EPMC4280614 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature