Precision medicine clinical trials: defining new treatment strategies.

ABSTRACT:

Objectives

To discuss the role of clinical trials in the changing landscape of cancer care resulting in individualized cancer treatment plans including a discussion of several innovative randomized studies designed to evaluate multiple targeted therapies in molecularly defined subsets of individuals.

Data sources

Medical and nursing literature, research articles, and clinicaltrials.gov.

Conclusion

Recent advancements in cancer biomarkers and biomedical technology have begun to transform fundamentals of cancer therapeutics and clinical trials through innovative adaptive trial designs. The goal of these studies is to learn not only if a drug is safe and effective but also how it is best delivered and who will derive the most benefit.

Implications for nursing practice

SUBMITTER: Heckman-Stoddard BM 

PROVIDER: S-EPMC4280791 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature