Preclinical development of AMG 139, a human antibody specifically targeting IL-23.

ABSTRACT:

Background and purpose

AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to determine the pharmacology, preclinical characteristics and safety of this monoclonal antibody.

Experimental approach

The in vitro pharmacology, pharmacokinetics (PK), pharmacodynamics and toxicology of AMG 139, after single or weekly i.v. or s.c. administration for up to 26 weeks, were evaluated in cynomolgus monkeys.

Key results

AMG 139 bound with high affinity to both human and cynomolgus monkey IL-23 and specifically neutralized the biological activity of IL-23 without binding or blocking IL-12. After a single dose, linear

SUBMITTER: Kock K 

PROVIDER: S-EPMC4280975 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature