Cortical and subcortical abnormalities in youths with conduct disorder and elevated callous-unemotional traits.

ABSTRACT:

Objective

Although there is growing evidence of brain abnormalities among individuals with conduct disorder (CD), the structural neuroimaging literature is mixed and frequently aggregates cortical volume rather than differentiating cortical thickness from surface area. The current study assesses CD-related differences in cortical thickness, surface area, and gyrification as well as volume differences in subcortical structures critical to neurodevelopmental models of CD (amygdala; striatum) in a carefully characterized sample. We also examined whether group structural differences were related to severity of callous-unemotional (CU) traits in the CD sample.

Method

Participants were 49 community adolescents aged 10 to 18 years, 22 with CD and 27 healthy comparison youth. Struct

SUBMITTER: Wallace GL 

PROVIDER: S-EPMC4281036 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature