Transcriptomic profiling facilitates classification of response to influenza challenge.

ABSTRACT:

Unlabelled

Despite increases in vaccination coverage, reductions in influenza-related mortality have not been observed. Better vaccines are therefore required and influenza challenge studies can be used to test the efficacy of new vaccines. However, this requires the accurate post-challenge classification of subjects by outcome, which is limited in current methods that use artificial thresholds to assign 'symptomatic' and 'asymptomatic' phenotypes. We present data from an influenza challenge study in which 22 healthy adults (11 vaccinated) were inoculated with H3N2 influenza (A/Wisconsin/67/2005). We generated genome-wide gene expression data from peripheral blood taken immediately before the challenge and at 12, 24 and 48 h post-challenge. Variation in symptomatic scoring was foun

SUBMITTER: Davenport EE 

PROVIDER: S-EPMC4281383 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature